Pure Collagen

Benefits of Pure Collagen:

• Improved cartilage tissue
• Reduced joint pain
• Improved bone density
• Reduced Cellulite
• Improved hair growth 
• Supports leaky gut repair
• Improved mobility

We will break down the research below based on our 3 featured collagen bioactive compounds: FORTIGEL, FORTIBONE, VERISOL

FORTIGEL

Penn State study confirms improvement of mobility with FORTIGEL®

At Penn State University (USA, 2008), 147 athletes were recruited who experienced activity-related joint pain. Those athletes (mean age 20.1 years) were subdivided into one group taking FORTIGEL® as a nutritional supplement and a control group taking a placebo for 24 weeks. The severity of symptoms was rated both by the treating physician and by the study participants with a visual analogue scale.

In this prospective, randomized, double-blind, placebo-controlled study, there was a statistically significant difference of pain perception between treatment and control groups. When utilizing alternative therapies such as hydrotherapy, massage and ice and heat packs, there was a clear-cut difference between the treatment and the placebo group in favor of the FORTIGEL® group. 

McAlindon proves long term effect of FORTIGEL®

In a study published in March 2011 by McAlindon and colleagues, the long term effect of FORTIGEL® treatment on the composition of hyaline cartilage in individuals with early knee osteoarthritis was investigated. This prospective, randomized, double-blind, placebo-controlled pilot study was performed at the Tufts Medical Center in cooperation with Harvard University.

A specific type of magnetic resonance imaging (dGEMRIC) was utilized in order to visualize structural changes in cartilage tissue of the respective study participants. Overall, 30 subjects were randomized into one group receiving 10 g FORTIGEL® a day for 48 weeks and a control group receiving a placebo. Three MRI scans of the knee were performed on each subject, one at baseline, one at 24 weeks with the final scan at 48 weeks.

The analysis of the cartilage scans revealed a statistically significant increase in proteoglycan density in the medial and lateral tibial regions of the FORTIGEL® treated subjects compared to the placebo group. Results indicate that oral supplementation of FORTIGEL® has a direct impact on human cartilage tissue. This confirms previous experimental data and clearly demonstrates that specific orally administered collagen peptides can have an influence on cartilage tissue regeneration. 

University of Freiburg, Germany confirms mobility improvement in young adults

Intention of placebo-controlled, randomized, double-blind, observational trial on 160 subjects at the Institute for Sports and Sports Science, University of Freiburg, Germany was to investigate the effect of orally administered Bioactive Collagen Peptides (BCP®) on young adults suffering from diagnosed activity-related knee joint pain. In the study a daily dosage of 5 g FORTIGEL® or a placebo was orally administered for 12 duration of weeks. After 3, 6, and 12 weeks changes in pain, stiffness and physical function were evaluated in the FORTIGEL® group using the Western Ontario and McMaster Universities Index score (WOMAC)4.

The results of the study clearly demonstrate the efficacy of a daily intake of 5 g FORTIGEL® in the treatment of gon- and coxarthritis. After only 3 weeks of oral administration of the product a statistically significant improvement in pain, stiffness and physical function could be observed. Moreover, this positive effect of FORTIGEL® persisted and was even more pronounced after 6 and 12 weeks of treatment.

In more than 40 % of all patients a complete pain reduction was achieved and in 70 % a positive effect of the therapy could be demonstrated. Thus FORTIGEL® is an effective therapeutic approach for those suffering from knee- and hip conditions.

FORTIBONE

Clinically proven to promote bone health - 

A randomized, placebo-controlled, double-blinded study showed the potential of FORTIBONE®. Over a period of 12 months, 180 women with reduced bone mass participated in a therapy with daily intake of 5 g FORTIBONE® or placebo. Changes in bone mass density were measured in the spine and femoral neck of the participants detected by DXA scans.

FORTIBONE® consumption showed a significant improvement of bone density. The results showed a pronounced increase in BMD (Bone Mineral Density) after FORTIBONE® supplementation in women suffering from osteopenia or osteoporosis. The results indicate an anabolic effect. FORTIBONE® is an interesting option to counteract bone degeneration.

VERISOL

Higher skin elasticity

The first study with 69 women aged between 35 and 55 years revealed that VERISOL® leads to significantly higher skin elasticity – up to 15 % – compared to placebo treatment. This effect could be measured after just 4 weeks of treatment and persisted after 8 weeks of oral VERISOL® administration. Another 4 weeks after the last intake of the product, VERISOL® application still showed higher skin elasticity levels than in the placebo treated group.

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Proksch E., Segger D., Degwert J., Schunck M., Zague V., Oesser S. Skin Pharmacol Physiology, August 2013

Reduction of wrinkles

The second study with more than 100 women aged between 45 and 65 years shows that the oral administration of VERISOL® significantly reduces wrinkles after 4 weeks and leads to a significantly higher skin procollagen concentration.

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Proksch E., Schunck M., Zague V., Segger D., Degwert J., Oesser S. Skin Pharmacol Physiology, December 2013

Improved skin surface structure and decrease of cellulite

About 85 % of the global female adult population is affected by cellulite (the orange peel appearance of skin). Cellulite is a beauty aspect, not a disease, but many women suffer from this beauty flaw. Cellulite is mainly caused by dermal matrix disturbances, in combination with excess of subcutaneous fat, bulging into the dermis as well as excess of intersistal fluid.

VERISOL® supplementation has beneficial effects on the dermal extracellular matrix of the skin and can help to decrease cellulite. Contrary to current cellulite supplements that mainly address the aspects of excessive fat or microcirculation/drainage, VERISOL® directly stimulates the extracellular matrix formation in skin.

Significant decrease of cellulite score

A double blind, randomized, placebo controlled study with 105 women aged between 25 and 50 years shows that the daily oral intake of VERISOL® significantly decreases the cellulite score. The effect was measured after 3 and 6 months supplementation. VERISOL® has a beneficial effect on skin extracellular matrix and restores the normal structure of the dermis and subcutaneous tissue. VERISOL® supplementation also reduced the waviness of the skin, with first results visible after 3 months, but more pronounced after 6 months. With a daily dose of VERISOL® the appearance of cellulite women with a BMI < 25 was significantly reduced.

As part of the study, changes in the dermal density were investigated. The two ultrasound scans show side by side the skin of a participant in the placebo group compared to the skin of a participant from the VERISOL® group. The increase in elastin and collagen is clearly visible.

JOURNAL OF MEDICINAL FOOD, J Med Food 00 (0) 2015, 1–9, DOI: 10.1089/jmf.2015.0022, Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology

Michael Schunck, 1 Vivian Zague, 2 Steffen Oesser, 1 Ehrhardt Proksch, 3

Promoting growth and health of fingernails

For many women, well-groomed fingernails are an inseparable part of an attractive appearance. But many women suffer from cracked or chipped nails as well as nail peeling and nail roughness. The Bioactive Collagen Peptides (BCP®) VERISOL® can help to improve growth and health of fingernails.

The different positive effects of VERISOL® are shown in a recent study. The study shows a decrease of cracked and/or chipped nails after 2 months of treatment, reaching a decrease of 42 % after 6 months. Compared to the control group, the nail growth speed is increasing. VERISOL® led to a statistically significant improvement in nail growth after 3 months of treatment. At the same time, there’s a notable improvement in nail peeling and a clearly decreased nail edge irregularity. 80 % of the patients were completely satisfied and satisfied with VERISOL® treatment. 75 % of the women perceive their nails as longer, 71 % said their nails grew faster and became longer.

Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol.   2017;00:1–7.  https://doi.org/10.1111/jocd.12393

New randomized, placebo-controlled study shows that supplementation with the specific Bioactive Collagen Peptides (BCP®) VERISOL® can result in improved hair structure, by significantly increasing hair thickness and proliferation of human hair follicle cells.

The study was conducted on 44 healthy women aged between 39 and 75, who each received a daily dose of 2.5 g VERISOL® or placebo for 16 weeks. At the end of the supplementation period, the use of VERISOL® led to a significant increase in hair thickness, whereas a slight decrease was observed in the placebo group. The comparison of the two groups revealed a statistically significant increase in hair thickness in the VERISOL® group compared to placebo, confirming the benefits of VERISOL® to hair thickness, a key aspect of healthy hair appearance.

The in vitro test showed a statistically significant increase of 31% in the proliferation rates of human hair follicle cells after exposure to VERISOL® for 4 hours, compared with the untreated control cells. This suggests a positive effect of VERISOL® on hair metabolism, building on previous data showing Bioactive Collagen Peptides to increase mitochondrial activity of hair follicle cells.