Methyl Complete
A comprehensive formula featuring bioavailable folate, NAC, B vitamins and Betaine HCL to support methylation and healthy homocysteine levels
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1 at rise, 1 mid day
Contains 120 capsules which lasts 2 months with typical use.
Safety
- Safe with breastfeeding
- Safe during pregnancy
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Safe for Kids
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Benefits of Methyl Complete
- Provides key nutrients to help support healthy homocysteine metabolism
- Provides minerals that act as cofactors related to healthy homocysteine metabolism such as Zn and Mo
- Provides N-acetyl-L-cysteine (NAC) which is known to help aid renal clearance of homocysteine
- Mood support
- Neurotransmitter balance
- Cardiovascular Support
- Cognitive Function Support
Methyl Complete is a comprehensive formula that features L-5-methyltetrahydrofolate—a body-ready folate—along with N-acetyl-L-cysteine (NAC), vitamins B6 and B12, and betaine. Together, these nutrients support methylation and promote healthy homocysteine metabolism*
The vascular system is the body’s network of blood vessels and is comprised of arteries, veins, and capillaries that carry blood to and from the heart. Vascular health is a top priority for many patients focused on long-term health and vitality.*
To support vascular health, key factors that affect biomarkers should be monitored. Homocysteine—a nonprotein amino acid—is an important biomarker of cardiovascular and cognitive health.Pathways related to cellular methylation, a vital metabolic process critical for overall health and wellbeing, are connected to healthy metabolism of homocysteine.*
The human body utilizes several nutrients—folate, B2, B6, and B12— to properly metabolize homocysteine and maintain levels within a healthy range.Blood levels of homocysteine tend to be highest in individuals with a diet low in levels of those nutrients. Nutritional supplementation offers a targeted approach to help support healthy homocysteine levels and methylation.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
What Makes Methyl Complete Superior?
Benefits
Homocysteine is an intermediate compound that is normally metabolized via three different pathways. A small amount of homocysteine can be cleared via the kidneys. Several vitamins/cofactors (such as B6, B12, folate, and betaine) and minerals (such as Zn and Mo) are needed for the proper functioning of these pathways:*
The body manages homocysteine levels in different ways:
1) Folate-dependent remethylation Homocysteine receives a methyl group from 5-methyltetrahydrofolate (5-methyl THF) to form methionine—a reaction catalyzed by the enzyme methionine synthase (MS)—and requires the vitamins B2, B12, and 5-methyl THF. Methionine is then converted to S-adenosylmethionine (SAM), the main methyl donor in the cell.*
2) Folate-independent remethylation Homocysteine receives a methyl group from betaine and forms methionine, catalyzed by the enzyme betaine-homocysteine methyltransferase (BHMT). Methionine is then converted to SAM, the main methyl donor in the cell.*
3) Transsulfuration Homocysteine is irreversibly metabolized to form cysteine, facilitated by the enzymes cystathionine—cynthase (CBS) and cystathionine-lyase (CTH). This pathway requires vitamin B6.*
4) Renal clearance The nutrient NAC has been shown to support renal clearance of homocysteine.*
Remethylation of homocysteine to methionine is essential for the synthesis of SAM. Elevated homocysteine contributes to a build-up of S-adenosylhomocysteine (SAH), a by-product of all SAM-mediated methyltransferase reactions. SAH is a potent competitive inhibitor of almost all methylation reactions dependent on SAM as the methyl donor. Thus, reducing homocysteine may reduce the buildup of SAH in the cells and may help support healthy cellular methylation capacity.*
How to Use
Take 1 capsule twice daily
Research
References:
1. Ganguly P et al. Nutr J. 2015;14:6.
2. Seshadri S et al. N Engl J Med. 2002;346:476-83.
3. Selhub J et al. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000;71:614S-20S.
4. Stover PJ. J Nutr. 2009;139:2402-5.
5. Blom HJ et al. Overview of homocysteine and folate metabolism. J Inherit Metab Dis. 2011; 34:75-81.
6. Williams KT et al. New insights into the regulation of methyl group and homocysteine metabolism. J Nutr. 2007;137:311-4.
7. Hildebrandt W et al. Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status. Am J Clin Nutr. 2015;102:1014-24.
8. Ventura P et al. Urinary and plasma homocysteine and cysteine levels during prolonged oral N-acetylcysteine therapy. Pharmacology. 2003;68:105-14.
9. James SJ et al. J Nutr. 2002;132:2361S-6S.
10. Mason JB. Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. J Nutr. 2003; 133 Suppl 3:941S-7
