Reset Restore Renew Detox Packs

How detoxification works
We can think of the liver like a factory with two shifts. The first shift (Phase I) receives raw materials, processes them, and sends them on to the second shift (Phase II). However, some of the products that pass through the first shift are more harmful than the raw materials they started out as. So the second shift, or Phase II, needs to be functioning optimally in order to quickly get rid of these new, more damaging substances. If the liver’s detoxification pathways become overwhelmed, this can lead to an unwanted build-up of toxins in the body.

The unique blend of nutrients in the Reset, Restore, Renew Detox packs is specifically designed to support Phase II actions at dominance with 3 capsules of Ultimate Detox, along with one Phase 1 liver-gallbladder supportive blend, and 1 antioxidant blend ensuring Phase II is primed to function efficiently without excessive ramping up Phase I.

Highlights
• Taurine, methionine, MSM, & N-Acetyl-Cysteine (NAC): sulfur-containing amino acids and compounds,
which support the sulfation pathway of detoxification. Think of sulfur as an ‘escort’ the liver uses to tag
certain toxins for removal from the body. This pathway requires sufficient sulfur to function optimally.
• Glutathione: the body’s master antioxidant and free-radical scavenger, aided by glutamine & NAC
• Calcium-D-Glucarate: supports the glucuronidation pathway and inhibits an enzyme that can undo Phase
II detoxification in the colon. Glucuronic acid, which is part of this pathway, is another of the liver’s escort
molecules that binds to toxins and aids in their excretion.

• Vitamins C and E are two chief antioxidant vitamins that function
synergistically to protect cell membranes and DNA from the
damaging effects of toxins and heavy metals.
• Alpha Lipoic Acid regenerates vitamins C and E to prolong their activity. It also supplies sulfur molecules,
which support both phases of liver detoxification.
• N-Acetyl-Cysteine (NAC) is a foundational precursor to glutathione and helps to boost the detoxification and
elimination of mercury.
• Selenium, L-leucine & NAC help to protect the central nervous system from potential mercury build-up by
preventing its absorption and aiding in its excretion.
• Chelated minerals bound to methionine support the removal of heavy metals and provide important cofactors
for phase 2 liver detoxification, where the liver cells add another substance to a toxin to render it less harmful.
• Grape seed extract and green tea extract are potent antioxidants also known for their ability to protect
against heavy metal build-up.
• Curcumin is not only a powerful antioxidant, but it also enhances the absorption and antioxidant activity of
green tea extract.

Liver support
Methionine, vitamins B12 and B6 support methylation reactions critical for effective detoxification while methionine, vitamin B6 and artichoke help maintain healthy glutathione status.1
Additionally, as vitamin A precursors, the mixed carotenoids in this product, along with artichoke leaf extract, may induce sulfotransferase enzymes needed for detoxification and contains the sulfur-containing amino acid taurine, which is crucial for phase II conjugation.

Milk thistle (Silybum marianum) is one of the most well-researched protective herbs for hepatocytes and has even
demonstrated the ability to promote the regeneration of liver cells in subjects with hepatitis and other liver disorders,
possibly owing to increased hepatocyte protein synthesis.(2,3) Milk thistle has also been shown to protect against liver
cell injury from ethanol, acetaminophen, carbon tetrachloride or iron overload, and it inhibits the lipoxygenase enzyme,
giving it antioxidant and anti-lipid peroxidation effects.(3,4) Additional effects include aiding in bile flow, protecting against
fibrosis, reducing the production of inflammatory cytokines, and potentially increasing insulin sensitivity.(5)

Inositol is another beneficial compound for the liver. Rodent models of non-alcoholic fatty liver disease (NAFLD)
induced via a high-fructose diet show that inositol supplementation helps reduce the buildup of liver fat and expression
of genes related to fatty acid synthesis.6 Rodent models of type 2 diabetes indicate that inositol supplementation (along
with inositol hexaphosphate) increases liver reduced glutathione levels and reduces liver triglyceride accumulation and
serum alkaline phosphatase activity while significantly increasing hepatic superoxide dismutase and catalase activity,
resulting in the preservation of liver cell integrity and improved antioxidant status.(7)

Artichoke (Cynara scolymus) has been found to enhance glutathione peroxidase activity and decrease production of
reactive oxygen species. In a randomized, placebo-controlled trial, patients with non-alcoholic steatohepatitis (NASH)
treated with artichoke extract showed significant reductions in serum AST and ALT liver enzymes, total cholesterol,
LDL-C, systolic blood pressure and blood glucose levels.8 Like milk thistle, artichoke has been shown to have antioxidant,
choleretic and hepatoprotective properties and to potentially aid in the regeneration of liver cells.9

Beetroot (Beta vulgaris) is a valuable source of betaine (trimethylglycine), which can act to reduce fatty infiltration
and degeneration of the liver, as well as help to thin the bile for improved gallbladder function.10,11 Rodent models of
chemically-induced liver injury show that beetroot extract attenuates oxidative stress, inflammation and apoptosis
in hepatocytes, increases levels of glutathione and other antioxidant enzymes, and attenuates the increase in lipid
peroxidation, nitric oxide synthesis and pro-inflammatory cytokines seen in rodents not treated with beetroot.12,13

Research in human liver cell lines in vitro suggests that betanin, a major component of beetroot, is responsible for some
of the hepatoprotective effects by activating the nuclear factor erythroid-2-related factor 2 (Nrf2)-antioxidant response
element (ARE) pathway.

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Detox Antiox™
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